QiShenYiQi Pill Improves Myocardial Hypertrophy Caused by Pressure Overload in Rats
نویسندگان
چکیده
Pressure-overloaded myocardial hypertrophy is an independent risk factor for various cardiovascular diseases (CVDs), such as heart failure (HF), arrhythmia, and even sudden death. It reported that QiShenYiQi pill (QSYQ) widely used in the treatment of CVDs can prevent pathological myocardium, but its specific mechanism still unclear. In this study, a rat model was established through pressure overload caused by abdominal aortic constriction Wistar rats. The rats were randomly divided into group, valsartan QSYQ sham-operated animals served control group. At 4 8 weeks intervention, general morphology heart, collagen content, volume (CVF), type I, III, changes, expression ANP, β-MHC, TGF-β1, CTGF analyzed, respectively, order to explore possible effect on hypertrophy. We observed could effectively improve pressure-overloaded rats, which related regulatory TGF-β1 CTGF.
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ژورنال
عنوان ژورنال: Evidence-based Complementary and Alternative Medicine
سال: 2021
ISSN: ['1741-427X', '1741-4288']
DOI: https://doi.org/10.1155/2021/5536723